Rivaroxaban Intermediate CAS 446292-08-6 Purity >99.0% (HPLC)

Short Description:

Chemical Name: Rivaroxaban Intermediate

CAS: 446292-08-6

Purity: >99.0% (HPLC)

Appearance: White Solid Powder

Intermediate of Rivaroxaban (CAS: 366789-02-8)

Contact: Dr. Alvin Huang

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446292-08-6 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Rivaroxaban Intermediate (CAS: 446292-08-6) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Rivaroxaban Intermediates, Please contact: alvin@ruifuchem.com

446292-08-6 - Chemical Properties:

Chemical Name	4-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-Morpholinone
Synonyms	(S)-2-({2-Oxo-3-[4-(3-oxomorpholino)phenyl]oxazolidin-5-yl}methyl)isoindoline-1,3-dione; 2-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione; Rivaroxaban Intermediate 5; Rivaroxaban Phthalimido Impurity; Rivaroxaban Related Compound G
Stock Status	In Stock, Commercial Production
CAS Number	446292-08-6
Molecular Formula	C22H19N3O6
Molecular Weight	421.40 g/mol
Melting Point	218.0~223.0℃
Density	1.465±0.06 g/cm3
COA & MSDS	Available
Place of Origin	Shanghai, China
Brand	Ruifu Chemical

446292-08-6 - Specifications:

Items	Specifications	Results
Appearance	White Solid Powder	White Solid Powder
Purity / Analysis Method	>99.0% (HPLC)	99.71%
Melting Point	218.0~223.0℃	220.2~221.0℃
Loss on Drying	<0.50%	0.08%
Residue on Ignition	<0.10%	0.06%
Individual Impurity	<0.50%	0.21%
Enanthiomeric Impurity	<0.20%	0.06%
Infrared Spectrum	Consistent with Structure	Complies
NMR Spectrum	Consistent with Structure	Complies
Conclusion	The product has been tested and complies with the given specifications
Application	Intermediate of Rivaroxaban (CAS: 366789-02-8)

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

446292-08-6 - Application:

Rivaroxaban Intermediate (CAS: 446292-08-6) is an important intermediate for the synthesis of Rivaroxaban (CAS: 366789-02-8), which is an anticoagulant and the first orally active direct factor Xa inhibitor. Rivaroxaban, a FXa inhibitor, is the active ingredient in XARELTO Tablets. XARELTO a kind of orally anticoagulant drug which is used for the prevention of blood clots. Rivaroxaban takes effect through competitively inhibiting free and clot bound factor Xa, which is needed to activate prothrombin (factor II) to thrombin (factor IIa). The later is a serine protease that is required to activate fibrinogen to fibrin, which is the loose meshwork that completes the clotting process.